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Increasing cases of SARS-CoV-2 breakthrough infections from immunization with predominantly spike protein based COVID-19 vaccines highlight the need for alternative vaccines using different platforms and/or antigens. In this study, we expressed SARS-CoV-2 spike and nucleocapsid proteins in a novel vaccinia virus ACAM2000 platform (rACAM2000). Following a single intramuscular immunization, the rACAM2000 co-expressing the spike and nucleocapsid proteins induced significantly improved protection against SARS-CoV-2 challenge in comparison to rACAM2000 expressing the individual proteins in a hamster model, as shown by reduced weight loss and quicker recovery time. The protection was associated with reduced viral loads, increased neutralizing antibody titre and reduced neutrophil-to-lymphocyte ratio. Thus, our study demonstrates that the rACAM2000 expressing a combination of the spike and nucleocapsid antigens is a promising COVID-19 vaccine candidate and further studies will investigate if the rACAM2000 vaccine candidate can induce a long lasting immunity against infection of SARS-CoV-2 variants of concern.
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In order to quantify the hydrochemical characteristics of groundwater in Hailun, analyze the hydrochemical process, and evaluate its health risks associated with nitrate intake, 77 shallow groundwater samples were collected and analyzed. The results show that groundwater in the study area is weakly acidic and groundwater chemical type was dominated by HCO3-Ca, HCO3â¢Cl-Ca, HCO3-Caâ¢Na and HCO3â¢Cl-Caâ¢Na. Rock weathering and dissolution, ion exchange, and human activities are the main reasons affecting the chemical composition of shallow groundwater in Hailun. The weathering and dissolution process of silicate under weakly alkaline conditions is the source of Na. The dissolution of calcite, dolomite, and gypsum are the main form of water-rock interaction. Results of health risk assessment show that the HQ value for adult males, adult females, children, and infants were in range of 0-1.52, 0-1.75, 0-3.58 and 0-6.08, respectively, and with a mean value of 0.19, 0.22, 0.44, 0.75, respectively. The harm of NO3 pollution is in the order of infant > child > adult female > adult male. The results of this study made local governments pay attention to drinking water safety issues for local residents.
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Água Subterrânea , Poluentes Químicos da Água , Adulto , Criança , China , Monitoramento Ambiental , Feminino , Humanos , Masculino , Nitratos/análise , Poluentes Químicos da Água/análiseRESUMO
The Coronavirus Disease 2019 (COVID-19), caused by the novel SARS-CoV-2, continues to spread globally with significantly high morbidity and mortality rates. Immunological surrogate markers, in particular antigen-specific responses, are of unquestionable value for clinical management of patients with COVID-19. Here, we investigated the kinetics of IgM, IgG against the spike (S) and nucleoproteins (N) proteins and their neutralizing capabilities in hospitalized patients with RT-PCR confirmed COVID-19 infection. Our data show that SARS-CoV-2 specific IgG, IgM and neutralizing antibodies (nAbs) were readily detectable in almost all COVID-19 patients with various clinical presentations. Notably, anti-S and -N IgG, peaked 20-40 day after disease onset, and were still detectable for at least up to 70 days, with nAbs observed during the same time period. Moreover, nAbs titers were strongly correlated with IgG antibodies. Significantly higher levels of nAbs as well as anti-S1 and N IgG and IgM antibodies were found in patients with more severe clinical presentations, patients requiring admission to intensive care units (ICU) or those with fatal outcomes. Interestingly, lower levels of antibodies, particularly anti-N IgG and IgM in the first 15 days after symptoms onset, were found in survivors and those with mild clinical presentations. Collectively, these findings provide new insights into the characteristics and kinetics of antibody responses in COVID-19 patients with different disease severity.
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Objective@#To perform lymphocyte micronucleus analysis on radiation workers with long-term exposure to low doses ionizing radiation, Evaluate the health condition of radiation workers, and provide the evidence for strengthening surveillance of radiation workers.@*Methods@#From January 1, 2013 to December 21, 2016, a statistical analysis and evaluation was conducted of the peripheral lymphocytes micronucleus rate in 5 901 radiation workers who had undergone medical examinations of employees at Chinese Academy of Medical Sciences Institute of Radiation Medicine.@*Results@#The micronucleus rates in radiation workers of the on-job group were higher than the pre-job group (P<0.01) . Significant difference was found among the different sex (t=5.97) , different types (χ2=378.69) , different levels of work units (χ2=115.48) . Significant difference was found among the micronucleus rates of 672 radiation workers of the on-job group from 2013 to 2016 (χ2=92.57, P<0.01) .@*Conclusion@#The peripheral lymphocytes micronucleus rate of radiation workers were significantly higher than non-contact workers. Significant increasing trend of micronucleus rates was noted among the radiation worker with increasing exposure time. The peripheral lymphocytes micronucleus rates of interventional therapy workers were highest. The peripheral lymphocytes micronucleus rates of Private hospitals workers were highest. This phenomenon deserves attention. Protection needs to be strengthened to ensure the health of radiation workers.
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Objective To compare four therapies for elderly patients with cerebellar hemorrhage breaking into the ventricles.Methods Clinical data of 158 elderly patients with severe spontaneous cerebellar hemorrhage breaking into the ventricles were retrospectively analyzed.There were 28 cases in the conservative management (CM) group and 130 cases in the surgical therapy (ST) group with an external ventricular drainage (EVD) subgroup (n=40),an external ventricular drainage combined with intraventricular fibrinolysis (EVD + IVF) subgroup (n =43),and a clot evacuation (CE) subgroup (n=47).The mortality at 1 month and modified Rankin Scale (mRS) at 6 months were employed to evaluate clinical effectiveness.In addition,statistical analysis of correlative factors for prognosis was conducted.Results The 1-month mortality (x2 =7.529,P =0.006) and 6-month mRS in the CM group (x2 =4.819,P =0.028) were significantly higher than those in the ST group.There was no significant difference in mortality after one month among the three ST subgroups (x2 =0.143,P=0.931),whereas significant differences were observed in 6-month mRS among them (x2 =7.209,P=0.027),and the scale in the EVD+IVF subgroup was significantly lower than in the CE and EVD subgroups.The incidence of complications such as pulmonary infections and stress ulcers in the CM group was significantly higher than in the ST group.Statistical differences were found in the incidence of pulmonary infections among the three ST subgroups (x2 =6.694,P=0.035),and the incidences in the EVD subgroup and the EVD+IVF subgroup were lower than the incidence in the CE subgroup.Nevertheless,there was no significant difference in the incidence of stress ulcers among the three ST subgroups (x2 =0.547,P=0.776).Conclusions EVD+ IVF is an effective treatment for cerebellar hemorrhage breaking into the ventricles in elderly patients,especially for those who cannot withstand a craniotomy or those who have primary diseases.It may speed up the absorption of hematoma,and decrease the operative risk and the incidence of postoperative complications.
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Objective To explore the life quality of postoperative patients after a hypertensive cerebral hem-orrhage in the basal ganglia and the factors influencing it, so as to provide evidence for improving the life quality of such patients. Methods A total of 128 patients were studied retrospectively. Their gender, age, occupation, mari-tal status, education level, place of residence and family size were tabulated, as well as whether or not they were liv-ing with their children, smoking or drinking alcohol. Their household income was recorded along with their clinical condition during surgery ( midline shift, blood loss, operative time, whether a hernia occurred, consciousness, and whether bleeding broke into the ventricles. The SF-36 health measurement scale was used to evaluate the patients′life quality, and the factors influencing it were analyzed. Results Univariate analysis showed that: ( 1) Their physio-logical functioning ( PF) and global health ( GH) were mainly affected by age, marital status, family size, midline shift, quantity of cerebral hemorrhage, occurrence of herniation, consciousness and whether the hemorrhage broke in-to the ventricles. (2) Their physiological role (RP) was influenced by marital status, education background, household monthly income, midline shift, consciousness and whether the hemorrhage broke into the ventricles. (3) Pain (BP) was mainly affected by marital status and family size. (4) Social functioning (SF) was closely related to marital status, family size, consciousness and whether hemorrhage broke into the ventricles. (5) Their mental health (MH) was main-ly affected by the amount of bleeding, whether they were living with their children, the operation′s duration and whether the hemorrhage broke into the ventricles. (6) Their emotions (RE) were influenced by their consciousness and whether bleeding broke into the ventricles. (7) Their vitality (VT) was affected by their marital status, smoking, consciousness and whether the bleeding broke into the ventricles. Multivariate analysis showed that whether the hemorrhage broke into the ventricles was the most influential factor. Family size was also influential. Conclusions Age, number of family members, whether they are living with their children, and whether hemorrhage broke into the ventricles are all influen-tial in predicting the life quality of survivors of hypertensive cerebral hemorrhage in the basal ganglia.
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Cardiac arrhythmia is one of the most common cardiovascular diseases,with high morbidity and mortality,which threatens human health and lives. With the development of medicine, natural products are revealing ever-greater anti-arrhythmic benefits and potential. However,their targets have not been fully clarified. In the recent ten years ,scientists have been studying the molecular mechanisms of natural products that have been found to inhibit INa,ICa-L,Ito,IK1,IKr,IKM3,HERG channel current and steady state K+ current,promote IKs and IKATP,inhibit microRNA-1 expression and change cardiac microRNA expression profile,affect Na+-K+-ATPase and superoxide dismutase activity,inhibitβ receptor and angiotensinⅡ receptor,and regulate lipid metabolism,thus affecting cardiac rhythm and exerting anti-arrhythmic effect. This paper revies the research advances in the antiarrhythmic tar?gets of natural products.
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Objective:To investigate the effect of ulinastatin on liver and kidney function in the patients with traumatic hemorrhag-ic shock. Methods:Totally 110 patients with traumatic hemorrhagic shock were divided into the control group (n=55) and the obser-vation group (n=55) according to the random number table. The control group received the conventional anti-shock treatment, and the observation group received ulinastatin with intravenous injection by syringe pump additonally. The changes of heart rate, urine vol-ume, liver function, renal function and inflammatory cytokine levels in the two groups were observed before and after the operation. Results:The heart rate at the 3rd h and 6th h after the operation in the observation group was significantly lower than that before the treatment , and urine volume was aslo significantly more than that before the treatment. The postoperative AST, ALT and LDH at the 3rd h and 6th h in the observation group were significantly lower than those in the control group at the same period, and the difference was significant (P0. 05);the IL-6 levels on the 1st and 3rd day in the observation group were significantly higher than those before the surgery, however, lower than those in the control group with significant differences (P<0. 05). Conclusion: Ulinastatin has protective effect on liver and kidney function in the pa-tients with traumatic hemorrhagic shock, and can improve heart rate and urine output of the patients.
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Objective To summarize the safety and clinical therapeutic effect of advanced aged coronary heart disease(CHD) patients with angina recurrence after coronary artery bypass grafting (CABG).Methods The clinical data,arteriography and the interventional results of 9 aged patients with angina recurrence treated by CABG were retrospectively analyzed .Results There were 8 patients received intervention ,among them 5 patients received coronary artery intervention , another 3 patients received graft vessels intervention .During operation and hospitaliza-tion,angina recurrence,acute myocardial infarction,revascularization,complication and mortality were not observed in 8 patients who received intervention .All patients were followed up for 12 months,there were 3 patients had angina recurrence and cured by drugs , but had no acute myocardial infarction and revascularization .Conclusion The intervention for advanced aged patients after CABG is a safe and effective treatment .The advanced aged patients with angina recurrence need receive arteriography quickly and receive coronary artery interventional treatment or graft vessels interventional treatment .
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Objective: This study was performed to analyze the feasibility of elective nodal irradiation (ENI) for early-stage esophageal carcinoma (EEC), evaluate the curative effect of radiation therapy for EEC, and determine the causes of treatment failure. Methods:Data were collected from 123 patients with esophageal squamous cell carcinoma of clinical T1-2 N0-1 M0 stage. Patients were divided into two groups based on different types of radiation therapy. Among the 123 patients, 102 underwent involved field irradiation (IFI), whereas 21 received ENI. A comparative analysis of patients in the two groups was conducted. Results:In 123 patients, the one-, three-, and five-year overall survival rates were 87.8%, 47.2%, and 36.6%, respectively. By contrast, the one-, three-, and five-year local control rates were 89.4%, 67.5%, and 48.8%, respectively. After comparing the one-, three-, and five-year survival rates in the ENI patients (i.e., 90.5%, 47.6%, and 42.9%, respectively) with those in the IFI patients (i.e., 86.3%, 49.0%, and 35.2%, respectively), no significant difference was found (χ2=0.290, P=0.588 8). The results indicate that ENI possibly decreased nodal metastases (χ2=5.778, P=0.016). Conclusion:Three-dimensional conformal radiotherapy is one of the best therapeutic regimens of radiation for EEC. ENI is possibly effective for preventing regional nodal metastasis. Whether ENI leads to an improved overall survival needs further investigation.
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Objective To investigate the multi-drug resistance of Klebsiella strains and its mechanism.Methods Twenty strains of Klebsiella were isolated from the Affiliated Hospital of Medical College,Ningbo University from October 2009 to March 2011,in which 18 isolates were Klebsiella pneumonia and 2 were Klebsiella planticola. Drug sensitivity was determined by K-B tests. Drug resistant genes gyrA,parC (chromosome mediated) and aac( 6′)-I b-Cr,qnrA,qnrB,qnrS,qepA (plasmid mediated) were amplified by PCR and verified by direct automated fluorogenic sequencing. Results Resistance to β-1actams,aminoglycosides and quinolones was observed in 20 strains,and resistant rates were all above 80％.Klebsiella planticola strains were sensitive to imipenem and meropenem.Mutations of gyrA and parC genes existed in 18 strains (90％),and the positive rates of aac (6') -I b-C r,qnrB and qnrS were 60％ (12/20),20％ (4/20) and 20％ (4/20),respectively.Conclusion The mutations ofgyrA and parC genes may be the main cause of the resistance to quinolones in these strains.
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Objective To compare the safety and efficacy of carotid artery stenting (CAS) and carotid endarterectomy(CEA) for the treatment of carotid stenosis. Methods The electronic databases (PubMed, EMbase, Cochrane Central Register of Controlled Trials, CNKI, VIP and Wanfang) were searched in order to retrieve randomized controlled trials (RCTs) about comparing CAS and CEA for the treatment of carotid stenosis. Cochrane collaboration's RevMan 5.0.24 were used for analyzing data. Results Twelve RCTs totalling 6903 patients (3460 patients were randomized to CAS and 3443 randomized to CEA) with symptomatic or asymptomatic stenosis were included in the meta-analysis. There were significantly higher 30-day relative risks after CAS than after CEA for death or any stroke [RR=1.64, 95%CI (1.33-2.03), P＜0.00001] and for stroke [RR=1.70, 95%CI (1.34-2.14), P＜0.00001]. The relative risks of myocardial infarction [RR=0.62, 95%CI (0.39-0.97), P=0.04] and cranial neuropathy [RR=0.07, 95%CI (0.03-0.16), P＜0.00001] was significantly less after CAS than after CEA. The relative risks of death [RR=1.27, 95%CI (0.82-1.96), P=0.29] or disabling stroke within 30 days [RR=1.33, 95%CI (0.78-2.28), P=0.29] and any stroke or death at 1 year after the procedures [RR=0.96, 95%CI (0.63-1.46), P=0.84] did not differ significantly between CAS and CEA operation. Conclusions CEA remains the first choice for treatment of carotid stenosis for patients with low surgery risk. For patients with high surgery risk and unsuitable for surgery, CAS has more advantages. It is reasonable to view CAS and CEA as complementary rather than competing modes of therapy.
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Objective To establish the universal antibody against all subtypes of the influenza A viral hemagglutinins(HA). Methods All HA sequences from influenza viruses in common domains were analyzed to search for the most conservative re,on of the HA gene. The peptides conjugated to carrier proteins were used to immunize rabbits in order to obtain high titer antibody. Results The most conservative region among all influenza viruses HA genes were 14 amino acids located at the N-terminal of HA2. The antibody titer reached to 1 : 80 000 after 4 injections of the coupled peptides. The achieved antibody was demonstrated by Western blot to bind HA proteins of influenza virus subtypes H1-H13 specifically. Conclusion The universal antibody has been successfully established by immunizing the rabbits with most conservative peptides of HA protein coupled to carrier protein.
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Intracortical distribution of arteries were studied on thick sections prepared from brains of 11 newborns after injection and fixation. The results are as follows.1. Branches from the cerebral arteries form a pial arterial network on the cortical surface. The larger pial arteries are supplied with vasa-vasorum and perivascular vessels. They send out cortical and medullary arteries penetrating the cortex vertically from the surface.2. The distribution of arteries in the entire cortical area can be represented by the pattern observed in a single gyrus, which serves as a general rule. The cortical arteries arising from the pial arteries penetrate into the cortex vertically and are arranged regularly which appear as a brush border that curves with the cerebral surface in sections. The diameter of the long cortical arteries is 16～31 ?m, while that of the short ones is 7.5～15.4 ?m. All these arteries send out branches at right angles which anastomose with one another to form a dense polygonal or irregular vascular network.The medullary arteries pass directly through the cortex into medulla. The diameter of the long medullary arteries is 48～61 ?m and that of the short ones, 35～47 ?m. Those entering from the top of each gyrus pass directly to the deep medulla, whereas those from the sulcus to the junction between the cortex and medulla exhibit various degrees of curvature. The medullary arteries send out branches at right angle, which, in turn, form T-shaped bifurcations, interconnecting each other in an oblong lattice framework.3. The central arteries penetrate the base of the brain, fan out and arch upward to reach the corpus striatum. Arteries may penetrate into the thalamus from posteriolateral, inferio-medial or superior surface. They branch with acute angles and form dense network with polygonal, triangular, circular and irregular interspaces. The arteries of the internal capsule also branch at right angles, show "T" bifurcations after a short distance and form an oblong vascular network.
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For the study of venae cerebri profundae of the Chinese, 50 previously fixed adult cerebral hemispheres and 11 brains of the newborn were investigated. The adult cerebral hemispheres were dissected under the stereoscopic microscope. All the 11 brains of the newborn were treated within 24 hours after death. Six percent gelatin solution containing 6% vermilion was injected into arteria carotis interna while a mixture of Indian ink with 3% gelatin was injected into vena jugularis interna. The specimens were fixed, sectioned into slices of 1～3 mm thick, cleared and observed under stereoscopic microscope. The findings were summarized as follows:1. vena cerebri interna was mostly formed by the continuation of v. thalamostriata superior after it curved inward and backward. In 38.00%?6.86 of the cases it united with v. choroidea superior and v. septi pellucidi at the site of the curvature. In 32.00%?6.6 it didn't receive any veins. In 12.00%?4.60 it united with v. septi pellucidi and 80.00%?3.84 with v. choroidea superior, while other occurrences were rare.In 80.00%?5.66 of the cases, Vena cerebri interna took its course at the posterior margin of the interventricular foramen. The rest started at the anterior one third (12.00%?4.60)and middle one third (8.00%?3.84) of the thalamus respectively.The source, position and course of v. thalamostriata superior, v. choroidea superior, v. septi pellucidi and v. ventriculi lateralis medialis were observed and described.2. v. basalis was formed by the union of the v. cerebri anterior, v. cerebri media profunda and v. ventricularis lateralis inferior. 70% of v. cerebri anterior emptied into v. basalis whereas the other 30% into the adjacent venous sinuses. v. cerebri media profundae, most of which received vv. thalamostriata inferior, emptied into v. basalis in 68.00%?6.60 cases and the adjacent venous sinuses in 32.00%?6.60 v. ventricularis lateralis inferior emptied into v. basalis in 96.00%?2.77 cases and into v. cerebri magna in 2.00%?1.98, while in 2.00%?1.98 it was absent.3. The longitudinal anastomotic vein. was formed by the "T" shaped bifurcations of the small branches of v. thalamostriata superior, v. septi pellucidi and v. ventricularis lateralis medialis in the white matter within an area of 2 mm by the lateral angle of the lateral ventricle. It received numerous radially arranged small veins in the medulla of the cerebral hemisphere. The longer ones of these veins might extend to the cortex and anastomoses between them and superficial cortical veins were demonstrated.
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The cerebellar arteries including the arterial supply to the dentate nucleus had been studied on 103 Chinese brians (80 adults, 23 children) by dissection, angiography, clearing method and dissection under stereoscopic microscope. The following results were obtained:1. The superior cerebellar artery which arose mostly from the upper end of the basilar artery near the posterior cerebral artery was one(82.52?2.68％)or two (17.48?2.68％) in number on each side. It was grouped into simple-trunk type (one trunk on each side 69.90?4.52％), double-trunks type(two trunks on each side 4. 86?2.13％), and mixed type (one trunk on one side and two on the other 25.24?4.28％).It passed backward around the cerebral peduncle and was more frequently divided into lateral and medial branches.2. Most of the anterior inferior cerebellar arteries sprang from lower third (66.49?3.29％) and middle third (12.14?2.69％) of the basilar artery. The rest (15.06?2.69％) sprang from posterior inferior cerebellar and vertebral arteries and upper segment of the basilar artery. It was absent in 6.31?1.69％.3. The posterior inferior cerebellar artery arose mostly from the vertebral artery (77.18?2.92％)and was absent in 6.80?1.95％. It formed a loop at its original segment and gave off 1～4 branches to medulla oblongata.4. The middle inferior cerebellar artery was present in 17.48?3.95％ and occurred on both sides in two cases.The course, position, distribution of all arteries mentioned above and their interrelationships were observed.5. The arteries to the dentate nucleus might be derived mainly from the superior cerebellar artery, but the anterior and posterior inferior cerebellar arteries also contributed some branches to it. These branches were found mostly 5～6 in number on the superior surface and 3～5 in number on the inferior surface.
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The fossa of the lacrimal sac and the naso-lacrimal canal in 506 crania(1,012 sides)of the Chinese were measured.Among them,374 crania are adult male and 132 crania are adult female.The main results obtained are summarized as follows: 1.The fossa of the lacrimal sac: male female average (1)height 16.79mm 16.41mm 16.60mm (2)width 7.74mm 7.57mm 7.66mm (3)width of the portion of the lacri- mal bone 4.08mm 3.87mm 3.98 mm (4)width of the portion of the frontal process of maxilla 5.51mm 5.43mm 5.47mm (5)width of the part anterior to the crest of the frontal process of ma- xilla 7.22mm 6.69mm 6.96mm (6)width of the part posterior to the crest of lacrimal bone 6.93mm 6.80mm 6.87mm (7)deepness 3.44mm 3.34mm 3.39mm (8)thickness of the middle part of ant- erior lacrimal crest 5.68mm 5.22mm 5.45mm (9)distance from anterior ethmoidal foramen to the anterior border of trochlear fossa 20.54mm 20.28mm 20.41mm 2.The naso-lacrimal canal male female average (1)transverse width of the upper ori- fice 6.06mm 5.84mm 5.95mm (2)length 17.29mm 16.29mm 16.79mm (3)distance from the lower orifice to piriform aperture 7.79mm 7.92mm 7.86mm (4)length from the upper orifice to the floor of the inferior nasal me- atus 29.62mm 28.61mm 29.12mm
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The pterion of 739 crania of the Chinese (adult male 486 cases, adult female 181 cases and young specimen of both sexes 72 cases) was studied. The pterion in the form of spheno-parietal suture was highest in percentage (77.94?1.08％). The percentage of the form of epipteric bone (19.22?1.02％) was higher than that of the temporofrontal suture (2.03?0.36％). The K-form represented only in 0.81?0.23％. In the form of spheno-parietal suture, the percentage of the wide H-type was highest (57.98?1.28％). The form of epipteric bone was found to be more common in nonadults than in adults. The N-type occurred more frequently in the male adults than in the female adults. Region and side failed to show any statistical importance in the percentage distribution of other forms. The group with epipteric bones was divided into three main classes, namely, with a single os epiptericum, with double, or multiple ossa epipterica. The percentage of those with a single os epiptericum was much higher (82.04?2.28％) than that of the other two classes (15.14?2.12％ and 2.82?0.92％). In the forms of the single os epiptericum, os epiptericum posterius was found in 6.77?0.66％, os epiptericum typicum in 6.50?0.64％, and os epiptericum anterius in 2.30?0.39％. In the forms of the double ossa epipterica, the united type occurred in 2.50?0.41％ and the separated type in 0.41?0.16％. In the forms of the multiple ossa epipterica only the united type was found in 0.54?0.18％. The centre of pterion was situated at 30.1 mm behind and 11.7 mm above the fronto-zygomatic suture or 37.7 mm above the baseline. In the pterion region the presence of the canal for the anterior branch of the middle meningeal artery was 60.83?2.75％. The bony canal that lay opposite the centre of pterion occurred more frequently in percentage 44.27?2.80％ and that lied below and behind the centre of pterion was relatively small in number (6.69％ and 6.37％), however, that lay in front of the centre of ptetion occurred only in 0.96％.
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The intracranial portion of the vertebral arteries and the basillar artery of 103 Chinese (80 adults and 23 children) brains have been studied. The diameter of the intracranial portion of the vertebral artery on the left side is usually greater than that on the right side. The anterior spinal artery comes off mostly from the vertebral artery. It descends, slants medially and unites with the opposite artery to form a single anterior spinal artery in front of the anterior median fissure of the medulla oblongata. The vertebral artery usually gives off 1～3 medullary branches, which enter the medulla oblongata mostly through the posteriolateral sulcus. The blood supply of medulla oblongata has been discussed.In 57.50?5.53% of the adults, the union of the right and left vertebral arteries to form the basilar artery was found at the level of pons, while in children, 47.83?10.39% was found at the level of the lower border of pons. The labyrinth arteries arise mostly from the anterior inferior cerebellar arteries (77.50?2.95), and in rare cases, from the superior cerebellar or vertebral arteries. The pontine branches coming off from each side of the basilar artery are usually 3～4 in number.
